Personality and Genetics

Authors: Serretti, Alessandro; Calati, Raffaella; Ferrari, Barbara; De Ronchi, Diana

Source: Current Psychiatry Reviews, Volume 3, Number 2, May 2007 , pp. 147-159(13)

Publisher: Bentham Science Publishers

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Abstract:

In the last few years the correlation between personality and genetics has been largely investigated. Harm Avoidance seems to be strongly associated with the serotonin transporter gene. The 5-HT1A and the 5-HT3A serotonin receptors and the D2 and D4 dopamine receptors, seem to be also involved, even if results are less unequivocal. Novelty Seeking seems to be associated with dopamine D4 receptor gene, but also the D2 and D3 dopamine receptors, the 5-HT2A serotonin receptor, the MAO-A and the COMT genes have been hypothesized as involved in this trait. Studies on Reward Dependence, Persistence, Self-Directedness, Cooperativeness and Self- Transcendence dimensions are still conflicting. Though further studies are necessary to replicate and validate those results, genetic factors play an important role for specific susceptibilities of human personality.

Keywords: Personality; temperament; genetics; character; serotonin; dopamine

Document Type: Research article

DOI: http://dx.doi.org/10.2174/157340007780599087

Affiliations: 1: Institute of Psychiatry, University of Bologna,Viale Carlo Pepoli 5, 40123 Bologna, Italy.

Publication date: 2007-05-01

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Current Psychiatry Reviews publishes frontier reviews on all the latest advances on clinical psychiatry and its related areas e.g. pharmacology, epidemiology, clinical care, and therapy. The journal's aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all clinicians, psychiatrists and researchers in psychiatry.