Omega-3 Fatty Acids: Role in the Prevention and Treatment of Psychiatric Disorders

Abstract:

The purpose of this article is to review the current literature regarding the role of omega-3 (ω-3) fatty acids (mainly eicosapentaenoic acid and docosahexaenoic acid) in the etiology and treatment of psychiatric disorders. Omega-3 fatty acids are essential for normal structure and function of neuronal membranes. They also influence cell signaling and are precursors to the eicosanoids, which play important regulatory roles in a wide range of physiological functions. There has been considerable interest in the potential use of ω-3 fatty acids for the treatment of psychiatric disorders including depression, bipolar disorder, schizophrenia, borderline disorder, obsessive compulsive disorder and childhood developmental and psychiatric disorders. This article provides a critical review of the recent findings and discusses future directions and questions that remain unanswered.

Keywords: Schizophrenia; Phospholipid Metabolism; magnetic resonance spectroscopy (MRS); phosphomonoesters; mitogen-activated protein kinase (MAPK); Bipolar Disorder; Depression

Document Type: Research article

DOI: 10.2174/157340006776875969

Affiliations: 1: Department of Internal Medicine, Endocrine Research Unit, 5-194 Joseph, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USA.