The Role of Cytokine Network in the Pathophysiology of Schizophrenia

Author: Kim, Yong-Ku

Source: Current Psychiatry Reviews, Volume 1, Number 2, June 2005 , pp. 123-131(9)

Publisher: Bentham Science Publishers

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Abstract:

A growing body of evidence suggests that cytokines have a role in schizophrenia. Cytokines are involved in neurodevelopment, schizophrenic psychopathology, and neurodegeneration, and these processes are all part of the pathophysiology of schizophrenia. Cytokines modulate neuronal action, differentiation, and survival during neurodevelopment and are important factors in the processes of neurotoxicity and neurodegeneration. Cytokines also play a role in the activity and survival of neurons that utilize certain neurotransmitters, particularly dopamine, serotonin, and glutamate. This paper addresses the potential role of the cytokine network in the pathophysiology of schizophrenia.

Keywords: cytokine; antipsychotics; neurotransmitter; neurodegeneration; neurodevelopment; schizophrenia

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1573400054065604

Affiliations: 1: Department of Psychiatry, Korea University College of Medicine, Ansan Hospital, 516, Go-Jan Dong, Ansan City, Kyunggi Province, 425-070, Korea.

Publication date: 2005-06-01

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Current Psychiatry Reviews publishes frontier reviews on all the latest advances on clinical psychiatry and its related areas e.g. pharmacology, epidemiology, clinical care, and therapy. The journal's aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all clinicians, psychiatrists and researchers in psychiatry.