Endocrine Disorders in Sickle-Cell Disease

$71.00 plus tax (Refund Policy)

Buy Article:


Background: Sickle cell disease is a hemoglobinopathy of global importance due to its worldwide high prevalence. Endocrine and metabolic disorders may be associated with this disease, aggravating its clinical course. Objective: Evaluate the current knowledge about metabolic and endocrine derangements related to sickle cell anemia. Source: Literature search was performed in MEDLINE and SciELO databases, in the last 20 years, combining in different compositions the following terms: sickle cell disease, short stature, delayed puberty, diabetes mellitus, osteoporosis, hypothyroidism and adrenal dysfunction. Results: Endocrine disorders in sickle cell disease have multifarious causes: tissue hypoxia, chronic anemia, iron overload, high energy demand, genetic influence and malnourishment. Slow speed of growth and delayed puberty are frequent. The most common endocrine disorders in sickle cell disease are: growth delay, osteopenia and hypogonadism. Diabetes mellitus, thyroid and adrenal disorders are overall rare in this population. Conclusion: Recognition of an endocrine disturbance is of utmost importance in the follow-up of sickle cell disease patients. Thus, preventive measures, early diagnosis and replacement of specific hormonal deficiencies may be implemented contributing to a better quality of life for these patients.

More about this publication?
  • Current Pediatric Reviews publishes frontier reviews on all the latest advances in pediatric medicine. The journal's aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all researchers and clinicians in pediatric medicine.
Related content



Share Content

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
Cookie Policy
ingentaconnect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more