Discovery of New Therapeutic Targets by the Informational Spectrum Method

Authors: Veljkovic, Nevena; Glisic, Sanja; Prljic, Jelena; Perovic, Vladimir; Botta, Maurizio; Veljkovic, Veljko

Source: Current Protein and Peptide Science, Volume 9, Number 5, October 2008 , pp. 493-506(14)

Publisher: Bentham Science Publishers

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Abstract:

The field of bioinformatics has become a major part of the drug discovery pipeline playing a key role in improvement and acceleration of this time and money consuming process. Here we review the application of the informational spectrum method (ISM), a virtual spectroscopy method for structure/function analysis of proteins, in identification of functional protein domains representing candidate therapeutic targets for drugs against human immunodeficiency virus (HIV)-1, anthrax, highly pathogenic influenza virus H5N1 and cardiovascular diseases.

Keywords: Bioinformatics; target; electron-ion interaction potential; informational spectrum method; H5N1; HIV-1; anthrax

Document Type: Research article

Publication date: 2008-10-01