Single Nucleotide Polymorphisms (SNPs): History, Biotechnological Outlook and Practical Applications

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Abstract:

The recent introduction of molecular biology methods to pharmacology, to assess how DNA sequence variations can influence the response of an individual to a drug, has opened new dimensions in the evidence based analysis of goals, risks and benefits of drug therapy. The development of diagnostic test systems to identify patients at increased risk of adverse drug reactions, the application of genomic technologies to drug development, and the clarification of the mechanisms of drug action on cells represent actual challenges for both clinicians and researchers. In this review, we emphasize on the investigative tools of molecular biology-based pharmacology with particular reference to the development of single nucleotide polymorphisms (SNPs) and new developing trends of this technology.

Keywords: dna microarray; genotyping; pharmacogenetics; pharmacogenomics; polymerase chain reaction; restriction fragment length polymorphisms; single nucleotide polymorphisms

Document Type: Review Article

DOI: http://dx.doi.org/10.2174/1570160054864021

Affiliations: Institute of Pathology, Paediatric Pathology, University of Innsbruck, Muellerstrasse 44, A-6020 Innsbruck, Austria.

Publication date: September 1, 2005

More about this publication?
  • Current Pharmacogenomics provides comprehensive overviews of all current research on pharmacogenomics and pharmacogenetics. All areas of the field from pre-clinical to clinical research are covered, including related areas such as genomics, proteomics, target discovery, bioinformatics and novel diagnostics. This international journal is peer-reviewed and publishes both mini- and full review articles.

    The journal has become essential reading for all researchers and clinicians with interests in pharmacogenomics and pharmacogenetics.
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