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Strategies to Direct Angiogenesis within Scaffolds for Bone Tissue Engineering

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There is a profound need for orthopaedic grafting strategies due to various trauma and musculoskeletal diseases. Tissue engineering offers a promising avenue to develop viable grafts for bone repair. The transfer of bone tissue engineering strategies to clinical applications is limited by the failure to adequately vascularize scaffolds after implantation. This review focuses on the natural processes for bone and vessel formation as well as the microenvironmental cues and microscale fabrication techniques to properly coordinate these events towards successful vascularization of tissue engineered scaffolds.
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Keywords: Angiogenesis; bone; cell transplantation; growth factor delivery; microscale patterning; scaffold; tissue engineering

Document Type: Research Article

Publication date: 01 June 2013

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  • Current Pharmaceutical Design publishes timely in-depth reviews covering all aspects of current research in rational drug design. Each issue is devoted to a single major therapeutic area. A Guest Editor who is an acknowledged authority in a therapeutic field has solicits for each issue comprehensive and timely reviews from leading researchers in the pharmaceutical industry and academia.

    Each thematic issue of Current Pharmaceutical Design covers all subject areas of major importance to modern drug design, including: medicinal chemistry, pharmacology, drug targets and disease mechanism.
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