QSAR, Docking, and CoMFA Studies of GSK3 Inhibitors
Authors: Garcia, Isela; Fall, Yagamare; Gomez, Generosa
Source: Current Pharmaceutical Design, Volume 16, Number 24, August 2010 , pp. 2666-2675(10)
Publisher: Bentham Science Publishers
Abstract:GSK-3 inhibitors are interesting candidates to develop anti-Alzheimer compounds. GSK-3β are also interesting as antiparasitic compounds active against Plasmodium falciparum, Trypanosoma brucei, and Leishmania donovani; the causative agents for Malaria, African Trypanosomiasis and Leishmaniosis. The high number of possible candidates creates the necessity of Quantitative Structure-Activity Relationship models in order to guide the GSK3 (Glycogen Synthase Kinase 3 inhibitor) synthesis. In this work, we revised different computational studies for a very large and heterogeneous series of GSK-3Is. First, we revised QSAR studies with conceptual parameters such as flexibility of rotation, probability of availability, etc. We then used the method of regression analysis and QSAR studies in order to understand the essential structural requirement for binding with receptor. Next, we reviewed 3D-QSAR, CoMFA and CoMSIA with different compounds to find out the structural requirements for GSK-3 inhibitory activity.
Keywords: Alzheimer; Bisarylmaleimides; CDK-2; CDK-4; Docking; GSK-3; Image-Based Approach; Indirubin Analogues; Indirubin Derivatives; Multi-Target QSAR; Neurofibrillary tangles (NFTs); QSAR; QSAR Modeling; SAR; Thiadiazolidinone Derivatives; anti-Alzheimer compounds; fungi; parasitic
Document Type: Research Article
Affiliations: Department of Organic Chemistry, University of Vigo, Spain.
Publication date: August 1, 2010
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