Authors: Urruticoechea, A.; Alemany, R.; Balart, J.; Villanueva, A.; Vinals, F.; Capella, G.

Source: Current Pharmaceutical Design, Volume 16, Number 1, January 2010 , pp. 3-10(8)

Publisher: Bentham Science Publishers

Abstract:

The landscape of cancer treatment has dramatically changed over the last four decades. The age when surgery and radiotherapy were the only effective way to fight tumour growth has ended. A complex scenario where the molecular features of tumours seem to be the cornerstone of any therapy is now emerging. Here we provide an overview on the different approaches to cancer treatment. This review will help the reader to acknowledge the pivotal role of some classic cancer therapies, including surgery, radiation, chemotherapy and endocrine therapy, now better understood in the mechanims underpinning their efficacy. Following, we focus on the understanding of the value of systemic treatment and on an up-date on the novel, up-coming therapies of the current targeted therapy age, including new antibodies, small molecules, antiangiogenics and viral therapy. We briefly elaborate, finally, on new biomarkers development and how it should rule and determine the future of therapeutic research in cancer.

Keywords: Cancer therapy; chemotherapy; biomarkers; targeted therapy; virotherapy; antiagiogenesis

Document Type: Research article

DOI: http://dx.doi.org/10.2174/138161210789941847

Affiliations: 1: Translational Research Laboratory, Institut Catala d'Oncologia. Hospital Duran i Reynals. Av. Gran Via de L'Hospitalet 199-203 . 08907 L'Hospitalet de Llobregat. Spain.

Publication date: 2010-01-01

More about this publication?

• Current Pharmaceutical Design publishes timely in-depth reviews covering all aspects of current research in rational drug design. Each issue is devoted to a single major therapeutic area. A Guest Editor who is an acknowledged authority in a therapeutic field has solicits for each issue comprehensive and timely reviews from leading researchers in the pharmaceutical industry and academia.
  
  Each thematic issue of Current Pharmaceutical Design covers all subject areas of major importance to modern drug design, including: medicinal chemistry, pharmacology, drug targets and disease mechanism.

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