Use of MHC II Structural Features in the Design of Vaccines for Organ-Specific Autoimmune Diseases

Authors: Moustakas, Antonis K.1; Papadopoulos, George K.1

Source: Current Pharmaceutical Design, Volume 15, Number 28, October 2009 , pp. 3262-3273(12)

Publisher: Bentham Science Publishers

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Abstract:

The Major Histocompatibility Complex Class II locus is the primary genetic linkage to autoimmune diseases. Susceptibility to each such disease is linked to different alleles, with a few alleles showing also dominant protection. The design of vaccines for autoimmune diseases is a long sought-after goal. As knowledge about the pathogenesis of these diseases has increased, the tools for such an approach have of necessity been refined. We review below the structural essence of MHC II-linked autoimmune diseases which centers on the binding of antigenic peptides to the disease-linked MHC II proteins, and the consequent activation of cognate TCRs from pathogenic CD4+ T cells. The state of affairs in two organ-specific autoimmune diseases, type 1 diabetes, celiac disease are covered, including attempts to treat these via antigen-specific MHC II-guided measures. We offer a couple of testable suggestions as to how this approach could be improved.

Keywords: APL; autoimmunity; HLA; MHC; vaccines

Document Type: Research article

Affiliations: 1: Laboratory of Biochemistry and Biophysics Faculty of Agricultural Technology Epirus Institute of Technology GR47100 Arta, Greece.

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