The Oxidative Stress Menace to Coronary Vasculature: Any Place for Antioxidants?

Authors: Briasoulis, Alexandros; Tousoulis, Dimitris; Antoniades, Charalambos; Stefanadis, Christodoulos

Source: Current Pharmaceutical Design, Volume 15, Number 26, September 2009 , pp. 3078-3090(13)

Publisher: Bentham Science Publishers

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Abstract:

Oxidative stress is involved in the pathogenesis of atherosclerosis. A variety of antioxidants has been used in clinical studies, during the past few years, for the prevention and treatment of atherosclerosis. In small clinical studies it was found that both vitamins C and E may improve endothelial function in high risk patients. However, interventional trials have been controversial, with some positive findings, many null findings, and some suggestion of harm in certain high-risk populations. Therefore, treatment with antioxidant vitamins C and E should not be recommended for the prevention or treatment of coronary atherosclerosis. New antioxidant strategies are needed to clarify the exact role of antioxidant treatment in coronary atherosclerosis.

Keywords: Antioxidants; coronary artery disease; nitric oxide; endothelium

Document Type: Research article

DOI: http://dx.doi.org/10.2174/138161209789058057

Affiliations: 1: Athens University Medical School, 69 S. Karagiorga, 16675, Glifada, Athens, Greece.

Publication date: 2009-09-01

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Each thematic issue of Current Pharmaceutical Design covers all subject areas of major importance to modern drug design, including: medicinal chemistry, pharmacology, drug targets and disease mechanism.