Authors: Rizos, C. V.; Elisaf, M. S.; Liberopoulos, E. N.

Source: Current Pharmaceutical Design, Volume 15, Number 24, August 2009 , pp. 2815-2832(18)

Publisher: Bentham Science Publishers

Abstract:

Hypertension is one of the major risk factors for cardiovascular disease. Angiotensin receptor blockers (ARBs) are a class of antihypertensive drugs with established efficacy and favorable safety profile. Telmisartan, a member of the ARB family, holds some additional traits which differentiate it from the rest ARBs. A pivotal role in these characteristics plays its ability to partially activate the peroxisome proliferator activated receptor-γ, which in turn controls a number of metabolism-related genes. Indeed, telmisartan has shown a number of pleiotropic effects in experimental and clinical studies. These include the amelioration of insulin resistance, improvement of lipid profile and favorable fat redistribution. Moreover, telmisartan has been associated with beneficial effects on vascular function, cardiac remodeling and renal function. However, do all these pleiotropic effects translate into clinical benefit? Recent studies have tried to answer this question with promising but not definitive results.

Keywords: Angiotensin receptor blockers; cardiovascular disease; diabetes development; heart failure; pleiotropic effects; renal disease; stroke; telmisartan

Document Type: Research article

Affiliations: 1: Department of Internal Medicine, Medical School, University of Ioannina, Ioannina 45110, Greece.

Publication date: 2009-08-01

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• Current Pharmaceutical Design publishes timely in-depth reviews covering all aspects of current research in rational drug design. Each issue is devoted to a single major therapeutic area. A Guest Editor who is an acknowledged authority in a therapeutic field has solicits for each issue comprehensive and timely reviews from leading researchers in the pharmaceutical industry and academia.
  
  Each thematic issue of Current Pharmaceutical Design covers all subject areas of major importance to modern drug design, including: medicinal chemistry, pharmacology, drug targets and disease mechanism.

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