Authors: Tousoulis, Dimitris; Kampoli, Anna-Maria; Papageorgiou, Nikolaos; Papaoikonomou, Stavroula; Antoniades, Charalambos; Stefanadis, Christodoulos

Source: Current Pharmaceutical Design, Volume 15, Number 17, June 2009 , pp. 2037-2048(12)

Publisher: Bentham Science Publishers

Abstract:

Patients with diabetes mellitus (DM) type 2 have a high prevalence of coronary artery disease (CAD), as diabetes is implicated in the formation of atherosclerotic plaque. Hyperglycemia, elevated free fatty acid, increased amount of circulating end-glucosylated serum products and insulin resistance are the main mechanisms involved in the accelerated atherosclerotic process observed in type 2 DM patients. Novel treatments have been proposed to prevent and treat CAD in patients with diabetes, mainly in those with diabetes type 2. Several clinical trials have been designed in order to examine the effectiveness of these agents, such as angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers, glitazones, statins and antioxidants, but the results are still controversial.

Keywords: Diabetes; atherogenesis; statins; glitazones; antioxidants; coronary artery disease; diabetes mellitus; therapeutics

Document Type: Research article

DOI: http://dx.doi.org/10.2174/138161209788453185

Affiliations: 1: Athens University Medical School, Hippokration Hospital, Vasilissis Sofias 114, 115 28, Athens Greece.

Publication date: 2009-06-01

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• Current Pharmaceutical Design publishes timely in-depth reviews covering all aspects of current research in rational drug design. Each issue is devoted to a single major therapeutic area. A Guest Editor who is an acknowledged authority in a therapeutic field has solicits for each issue comprehensive and timely reviews from leading researchers in the pharmaceutical industry and academia.
  
  Each thematic issue of Current Pharmaceutical Design covers all subject areas of major importance to modern drug design, including: medicinal chemistry, pharmacology, drug targets and disease mechanism.

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