Authors: Andreassi, Maria G.; Gastaldelli, Amalia; Clerico, Aldo; Salvadori, Piero A.; Sicari, Rosa; Picano, Eugenio

Source: Current Pharmaceutical Design, Volume 15, Number 10, April 2009 , pp. 1131-1141(11)

Publisher: Bentham Science Publishers

Abstract:

Imaging and laboratory biomarkers are an essential support to modern practice of medicine, allowing a better identification, severity titration, staging and follow-up of atherosclerosis and heart failure disease. This review provides an overview of imaging, biochemical and genetic biomarkers used in clinical practice and for research purposes in order to evaluate the 4 different aspect of patient vulnerability to cardiovascular disease: arterial; blood; myocardial; metabolic vulnerability.

Yet, no single perfect biomarker exists and there is wide room for optimization and integration between clinical evaluation and biomarker evaluation. In general, a targeted approach tailored on the individual patient should be preferred to a carpet diagnostic bombing, which will lead to an exorbitant multiplier of costs, risks and inappropriate testing.

Keywords: Atherosclerosis; biomarkers; cost; risk

Document Type: Research article

DOI: http://dx.doi.org/10.2174/138161209787846937

Affiliations: 1: CNR, Institute of Clinical Physiology, Via Moruzzi, 1, 56124 Pisa, Italy.

Publication date: 2009-04-01

More about this publication?

• Current Pharmaceutical Design publishes timely in-depth reviews covering all aspects of current research in rational drug design. Each issue is devoted to a single major therapeutic area. A Guest Editor who is an acknowledged authority in a therapeutic field has solicits for each issue comprehensive and timely reviews from leading researchers in the pharmaceutical industry and academia.
  
  Each thematic issue of Current Pharmaceutical Design covers all subject areas of major importance to modern drug design, including: medicinal chemistry, pharmacology, drug targets and disease mechanism.

Related content

• In this: publication
• By this: publisher
• In this Subject: Pharmacology
• By this author: Andreassi, Maria G. ;  Gastaldelli, Amalia ;  Clerico, Aldo ;  Salvadori, Piero A. ;  Sicari, Rosa ;  Picano, Eugenio

Website © Publishing Technology. Article copyright remains with the publisher, society or author(s) as specified within the article.

• Terms and conditions
• Privacy policy
• Information for advertisers