Pleiotropic Effects of Fenofibrate

Authors: Tsimihodimos, V.; Liberopoulos, E.; Elisaf, M.

Source: Current Pharmaceutical Design, Volume 15, Number 5, February 2009 , pp. 517-528(12)

Publisher: Bentham Science Publishers

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Abstract:

Fenofibrate represents the most commonly used fibric acid derivative. The drug exerts its metabolic effects by modulating the expression of several genes involved in lipoprotein metabolism. In addition, numerous studies suggest that fenofibrate may also affect the progression of the atherosclerotic process by several lipid-independent mechanisms. This review considers the clinical pharmacology of fenofibrate and the current evidence on the pleiotropic effects of this fibric acid derivative.

Keywords: Fenofibrate; pleiotropic effects; inflammation; endothelial function; oxidative stress; lipoprotein-associated enzymes; cardiac remodeling; angiogenesis

Document Type: Research article

DOI: http://dx.doi.org/10.2174/138161209787315675

Affiliations: 1: Department of Internal Medicine, University of Ioannina, 451 10 Ioannina, Greece.

Publication date: 2009-02-01

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Current Pharmaceutical Design publishes timely in-depth reviews covering all aspects of current research in rational drug design. Each issue is devoted to a single major therapeutic area. A Guest Editor who is an acknowledged authority in a therapeutic field has solicits for each issue comprehensive and timely reviews from leading researchers in the pharmaceutical industry and academia.

Each thematic issue of Current Pharmaceutical Design covers all subject areas of major importance to modern drug design, including: medicinal chemistry, pharmacology, drug targets and disease mechanism.