Authors: David Dong, Zhao M.; Aplin, Alfred C.; Nicosia, Roberto F.

Source: Current Pharmaceutical Design, Volume 15, Number 4, February 2009 , pp. 365-379(15)

Publisher: Bentham Science Publishers

Abstract:

Angiogenesis during reactive and pathologic processes is characteristically associated with inflammation. Macrophages and dendritic cells present in the inflammatory infiltrate contribute to the angiogenic process by multiple mechanisms. Macrophages produce a broad array of angiogenic growth factors and cytokines, generate conduits for blood flow through proteolytic mechanisms, and promote the remodeling of arterioles into arteries. They can also inhibit angiogenesis and cause reabsorption of neovessels by inducing endothelial cell death. Dendritic cells can stimulate or inhibit angiogenesis depending on their activation status and subset specificity. Dendritic cells stimulate angiogenesis by secreting angiogenic factors and cytokines, promoting the proangiogenic activity of T lymphocytes, and trans-differentiating into endothelial cells. Inflammatory infiltrates associated with angiogenesis also contain Tie2+, VEGFR2+, and GR1+ myelomonocytic cells which actively regulate the angiogenic process through paracrine mechanisms. In this paper we review our current knowledge of this field and discuss how recent advances have provided the rationale for novel therapeutic approaches against cancer.

Keywords: Macrophages; dendritic cells; myeloid cells; neovascularization; arteriogenesis

Document Type: Research article

DOI: http://dx.doi.org/10.2174/138161209787315783

Affiliations: 1: Division of Pathology and Laboratory Medicine (S-113-Lab), VA Puget Sound Health Care System, 1660 South Columbian Way, Seattle, WA 98108, USA.

Publication date: 2009-02-01

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• Current Pharmaceutical Design publishes timely in-depth reviews covering all aspects of current research in rational drug design. Each issue is devoted to a single major therapeutic area. A Guest Editor who is an acknowledged authority in a therapeutic field has solicits for each issue comprehensive and timely reviews from leading researchers in the pharmaceutical industry and academia.
  
  Each thematic issue of Current Pharmaceutical Design covers all subject areas of major importance to modern drug design, including: medicinal chemistry, pharmacology, drug targets and disease mechanism.

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