Authors: Al Moustafa, Ala-Eddin; Kassab, Amal; Darnel, Andrew; Yasmeen, Amber

Source: Current Pharmaceutical Design, Volume 14, Number 22, August 2008 , pp. 2159-2172(14)

Publisher: Bentham Science Publishers

Abstract:

Human papillomaviruses (HPVs) are a group of host-specific DNA viruses, with more than 120 different types identified to date. HPVs are classified as high- or low-risk (HR or LR) depending on their potential to induce cancer. Persistent infections with HR types of HPVs present a major risk factor for the development of a variety of human cancers including cervical, colorectal, head and neck as well as breast cancers. On the other hand, the deregulation of ErbB family tyrosine kinase receptors has also been associated with several types of human cancers. For instance, ErbB2 has been shown to have an important role in human carcinomas, specifically breast cancer. Moreover, the E-cadherin/catenin complex plays a pivotal role in the maintenance of normal adhesion in epithelial cells, and has been demonstrated to suppress tumor invasion and participate in cell signaling in human carcinomas. This review focuses on the interaction between HRHPV/ ErbB2 tyrosine receptors and the E-cadherin/catenin complex in human carcinomas including cervical, colorectal, head and neck and breast cancers.

Keywords: HPV; ErbB receptors; E-cadherin/catenin complex; cervical cancer; colorectal cancer; head and neck cancer and breast cancer

Document Type: Research article

Affiliations: 1: Program in Cancer Genetics, McGill University and Montreal Center for Experimental Therapeutics in Cancer of the Lady Davis Institute for Medical Research of the Sir Mortimer B. Davis-Jewish General Hospital, 3755 Ch de la Cote Ste-Catherine, Mon

Publication date: 2008-08-01

More about this publication?

• Current Pharmaceutical Design publishes timely in-depth reviews covering all aspects of current research in rational drug design. Each issue is devoted to a single major therapeutic area. A Guest Editor who is an acknowledged authority in a therapeutic field has solicits for each issue comprehensive and timely reviews from leading researchers in the pharmaceutical industry and academia.
  
  Each thematic issue of Current Pharmaceutical Design covers all subject areas of major importance to modern drug design, including: medicinal chemistry, pharmacology, drug targets and disease mechanism.

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