The Role of Integrin-Mediated Cell Adhesion in Atherosclerosis: Pathophysiology and Clinical Opportunities

Authors: Lu, X.; Lu, D.; Scully, M. F.; Kakkar, V. V.

Source: Current Pharmaceutical Design, Volume 14, Number 22, August 2008 , pp. 2140-2158(19)

Publisher: Bentham Science Publishers

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Abstract:

Integrins have been reported to mediate cell survival, proliferation, differentiation, and migration programs. For this reason, the past few years have seen an increased interest in the implications of integrin receptors in atherosclerosis. This review considers the potential role of integrins in atherosclerosis and also addresses why integrins present attractive targets for drug design. It discusses the properties of the integrin-based chemotherapeutic agents currently under consideration clinically and endeavours to provide insights into development of cardiovascular drugs using integrins as targets.

Keywords: Integrin; Cell Adhesion; Atherosclerosis; proliferation; drug design; chemotherapeutic agents; cardiovascular drugs

Document Type: Research article

Affiliations: 1: Thrombosis Research Institute, Manresa Road, London, SW3 6LR UK.

Publication date: 2008-08-01

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Current Pharmaceutical Design publishes timely in-depth reviews covering all aspects of current research in rational drug design. Each issue is devoted to a single major therapeutic area. A Guest Editor who is an acknowledged authority in a therapeutic field has solicits for each issue comprehensive and timely reviews from leading researchers in the pharmaceutical industry and academia.

Each thematic issue of Current Pharmaceutical Design covers all subject areas of major importance to modern drug design, including: medicinal chemistry, pharmacology, drug targets and disease mechanism.