Authors: Zimmerman, S. A.; Ferry, J. G.

Source: Current Pharmaceutical Design, Volume 14, Number 7, March 2008 , pp. 716-721(6)

Publisher: Bentham Science Publishers

Abstract:

There are currently five (α,β,γ,δ,Ezgr;) classes of carbonic anhydrases (CA's) of which the α-class from mammalian sources has been studied to a much greater extent compared to the other four classes. Yet, CA's other than the α-class are widely distributed in Nature and play important roles in human health, the global carbon cycle, and industrial applications. In aerobic prokaryotes, β-class CA's are implicated in maintaining internal pH and CO2/bicarbonate balances required for biosynthetic reactions. In anaerobic prokaryotes, β- class CA's are implicated in the transport of CO2 and bicarbonate across the cytoplasmic membrane that regulates pH and facilitates acquisition of substrates and product removal required for growth. In phototrophic organisms, β-class CA's are particularly important for transport and concentration of CO2 and bicarbonate for photosynthesis. The δ- and ζ-classes are proposed to function in marine diatoms to concentrate CO2 for photosynthesis. Physiological roles for the γ-class are not as well documented; however, the active site architecture and catalytic mechanism is well understood as are patterns of inhibition by sulfonamides and anions.

Document Type: Research article

DOI: http://dx.doi.org/10.2174/138161208783877929

Affiliations: 1: Department of Biochemistry & Molecular Biology, Pennsylvania State University, 205 S. Frear Laboratory,University Park, PA 16802, USA.

Publication date: 2008-03-01

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  Each thematic issue of Current Pharmaceutical Design covers all subject areas of major importance to modern drug design, including: medicinal chemistry, pharmacology, drug targets and disease mechanism.

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