Authors: Paraskevas, Kosmas I.; Mikhailidis, Dimitri P.; Perrea, Despina

Source: Current Pharmaceutical Design, Volume 14, Number 4, February 2008 , pp. 325-337(13)

Publisher: Bentham Science Publishers

Abstract:

In the last 50 years, several experimental models of abdominal aortic aneurysms (AAAs) have been described. These models have aided scientists and physicians to understand the pathophysiological mechanisms underlying AAA development and progression. In addition, they have served as means for the development of a number of conservative (such as doxyxycline, marimastat and propranolol) and surgical treatment options for the management of AAAs. In the last few years, experimental models have contributed in the development of novel endovascular techniques for the treatment of AAAs. Animal models of endovascular grafts and percutaneous techniques comprise an essential step for the successful clinical application of these procedures. Additionally, they may comprise part of the training process for vascular surgeons.

The different experimental AAA models are briefly presented and their clinical significance is discussed. Experimental models play an essential role in the field of research for the development of more successful therapeutic alternatives for the management of AAAs.

Keywords: Abdominal aortic aneurysms; animal models; experimental; endovascular

Document Type: Research article

Publication date: 2008-02-01

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• Current Pharmaceutical Design publishes timely in-depth reviews covering all aspects of current research in rational drug design. Each issue is devoted to a single major therapeutic area. A Guest Editor who is an acknowledged authority in a therapeutic field has solicits for each issue comprehensive and timely reviews from leading researchers in the pharmaceutical industry and academia.
  
  Each thematic issue of Current Pharmaceutical Design covers all subject areas of major importance to modern drug design, including: medicinal chemistry, pharmacology, drug targets and disease mechanism.

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