Demystifying the ACE Polymorphism: From Genetics to Biology

Authors: Castellon, Raquel; Hamdi, Hamdi K.

Source: Current Pharmaceutical Design, Volume 13, Number 12, April 2007 , pp. 1191-1198(8)

Publisher: Bentham Science Publishers

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Abstract:

The angiotensin converting enzyme (ACE) I/D polymorphism has been one of the most studied genetic systems. It comprises hundreds of reports and a myriad of disease associations, including cardiovascular, metabolic, immune, cancer, aging, neurodegenerative and psychiatric diseases. Despite the wealth of information on the ACE polymorphism and the well-known functions of ACE, several questions arise. Why does the ACE polymorphism associate with so many diseases? What is its function? In this review, we summarize the current information on the ACE polymorphism and explain its function in the context of cell survival. We also provide a model to understand its role in biology and disease at the organism and population levels.

Keywords: cell survival; stem cells; vasculature; regeneration; aging; alu; mobile elements

Document Type: Research article

DOI: http://dx.doi.org/10.2174/138161207780618902

Affiliations: 1: H2RC Corporation, 1920 E.Katella Avenue, Suite U, Orange CA, 92867 USA.

Publication date: 2007-04-01

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Current Pharmaceutical Design publishes timely in-depth reviews covering all aspects of current research in rational drug design. Each issue is devoted to a single major therapeutic area. A Guest Editor who is an acknowledged authority in a therapeutic field has solicits for each issue comprehensive and timely reviews from leading researchers in the pharmaceutical industry and academia.

Each thematic issue of Current Pharmaceutical Design covers all subject areas of major importance to modern drug design, including: medicinal chemistry, pharmacology, drug targets and disease mechanism.