Authors: Cross, K. J.; Huq, N. L.; Reynolds, E. C.

Source: Current Pharmaceutical Design, Volume 13, Number 8, March 2007 , pp. 793-800(8)

Publisher: Bentham Science Publishers

Abstract:

The casein phosphopeptides (CPP) are derived from the milk protein casein by tryptic digestion. The CPP, containing the sequence -Pse-Pse-Pse-Glu-Glu- where Pse is a phosphoseryl residue, stabilize calcium and phosphate ions in aqueous solution and make these essential nutrients bioavailable. Under alkaline conditions the calcium phosphate is present as an alkaline amorphous phase complexed by the CPP, referred to as casein phosphopeptide-amorphous calcium phosphate (CPP-ACP). The CPP-ACP complexes readily incorporate fluoride ions forming casein phosphopeptideamorphous calcium fluoride phosphate (CPP-ACFP). A mechanism is discussed which provides a rationale for the ability of the CPP-ACP to remineralize carious lesions in dental enamel. Clinical applications of the CPP-ACP as agents in the treatment of dental caries and other hypomineralized conditions are reviewed. It is concluded that the CPP are a safe and novel carrier for calcium, phosphate and hydroxide (fluoride) ions to promote enamel remineralization with application in oral care products, dental professional products and foodstuffs.

Keywords: Anticariogenic casein phosphopeptides; calcium phosphate delivery vehicle; structure; clinical studies nanocomplex

Document Type: Research article

DOI: http://dx.doi.org/10.2174/138161207780363086

Affiliations: 1: Centre for Oral Health Science,School of Dental Science, The University of Melbourne, 720 Swanston Street, Victoria, 3000, Australia.

Publication date: 2007-03-01

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  Each thematic issue of Current Pharmaceutical Design covers all subject areas of major importance to modern drug design, including: medicinal chemistry, pharmacology, drug targets and disease mechanism.

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