Nitric Oxide and the Regulation of Apoptosis in Tumour Cells

Authors: Tarr, J. M.; Eggleton, P.; Winyard, P. G.

Source: Current Pharmaceutical Design, Volume 12, Number 34, December 2006 , pp. 4445-4468(24)

Publisher: Bentham Science Publishers

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Abstract:

Nitric oxide (NO) is a small, highly reactive, diffusible free radical which has been implicated in many physiological and pathophysiological processes. It has either pro-apoptotic or anti-apoptotic effects on cells, depending upon a host of factors. This review outlines some of the regulatory molecules and organelles involved in the apoptotic pathways that can be influenced by the presence of NO, including p53, Bcl-2, caspases, mitochondria, and heat shock proteins. The effects of NO on the apoptosis of tumour cells are also examined.

Keywords: Nitric Oxide; Apoptosis; Nitric Oxide Synthase; Tumour Cells

Document Type: Research article

DOI: http://dx.doi.org/10.2174/138161206779010477

Affiliations: 1: Institute of Biomedical and Clinical Science, Peninsula Medical School, Universities of Exeter and Plymouth, Exeter, Devon, EX1 2LU, UK.

Publication date: 2006-12-01

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Current Pharmaceutical Design publishes timely in-depth reviews covering all aspects of current research in rational drug design. Each issue is devoted to a single major therapeutic area. A Guest Editor who is an acknowledged authority in a therapeutic field has solicits for each issue comprehensive and timely reviews from leading researchers in the pharmaceutical industry and academia.

Each thematic issue of Current Pharmaceutical Design covers all subject areas of major importance to modern drug design, including: medicinal chemistry, pharmacology, drug targets and disease mechanism.