Authors: Roger, Sebastien; Potier, Marie; Vandier, Christophe; Besson, Pierre; Le Guennec, Jean-Yves

Source: Current Pharmaceutical Design, Volume 12, Number 28, October 2006 , pp. 3681-3695(15)

Publisher: Bentham Science Publishers

Abstract:

Early detection and treatment of cancers have increased survival and improved clinical outcome. The development of metastases is often associated with a poor prognostic of survival. Finding early markers of metastasis and developing new therapies against their development is a great challenge. Since a few years, there is more evidence that ionic channels are involved in the oncogenic process. Among these, voltage-gated sodium channels expressed in non-nervous or non-muscular organs are often associated with the metastatic behaviour of different cancers. The aim of this review is to describe the current knowledge on the functional expression of voltage-gated sodium channels and their biological roles in different cancers such as prostate, breast, lung (small cells and non-small cells) and leukaemia. In the conclusion, we develop conceptual approaches to understand how such channels can be involved in the metastatic process and conclude that blockers targeted toward these channels are promising new therapeutic solutions against metastatic cancers.

Keywords: Cancers; voltage-gated sodium channels; TTX; metastasis; invasivity; motility; galvanotaxis

Document Type: Research article

Affiliations: 1: Inserm E 211 Nutrition Croissance Cancer, Faculte de Medecine, 10 Bd Tonnelle, 37032 Tours, France.

Publication date: 2006-10-01

More about this publication?

• Current Pharmaceutical Design publishes timely in-depth reviews covering all aspects of current research in rational drug design. Each issue is devoted to a single major therapeutic area. A Guest Editor who is an acknowledged authority in a therapeutic field has solicits for each issue comprehensive and timely reviews from leading researchers in the pharmaceutical industry and academia.
  
  Each thematic issue of Current Pharmaceutical Design covers all subject areas of major importance to modern drug design, including: medicinal chemistry, pharmacology, drug targets and disease mechanism.

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