Target Organ Damage in Hypertension: Pathophysiology and Implications for Drug Therapy

Authors: Nadar, Sunil K.; Tayebjee, Muzahir H.; Messerli, Franz; Lip, Gregory Y.H.

Source: Current Pharmaceutical Design, Volume 12, Number 13, May 2006 , pp. 1581-1592(12)

Publisher: Bentham Science Publishers

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Abstract:

Hypertension is a well known risk factor for cardiovascular and cerebrovascular events such as heart attacks and strokes. In addition, it is associated with earlier changes in organ systems in the body, such as left ventricular hypertrophy (LVH), proteinuria and renal failure, retinopathy and vascular dementia which are grouped under the term "target organ damage"(TOD).

There are many processes involved in the pathogenesis of TOD and these include endothelial activation, platelet activation, increased thrombogenesis, changes in the renin aldosterone angiotensin system (RAAS), and collagen turnover. All these changes work hand in hand and lead to the production of hypertensive TOD. In this review, we aim to provide an overview of the recent advances in pathophysiology of hypertensive TOD, and examine how these changes lead to the production of TOD. A better understanding of these pathogenic processes would help us better devise treatment strategies in preventing the dreaded complications associated with hypertension.

Keywords: Hypertension; target organ damage; endothelial activation; platelet activation

Document Type: Research article

DOI: http://dx.doi.org/10.2174/138161206776843368

Affiliations: 1: Haemostasis, Thrombosis, and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham B18 7QH, UK.

Publication date: 2006-05-01

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Current Pharmaceutical Design publishes timely in-depth reviews covering all aspects of current research in rational drug design. Each issue is devoted to a single major therapeutic area. A Guest Editor who is an acknowledged authority in a therapeutic field has solicits for each issue comprehensive and timely reviews from leading researchers in the pharmaceutical industry and academia.

Each thematic issue of Current Pharmaceutical Design covers all subject areas of major importance to modern drug design, including: medicinal chemistry, pharmacology, drug targets and disease mechanism.

Target Organ Damage in Hypertension: Pathophysiology and Implications for Drug Therapy

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