The Puzzle of Asthma Treatment: Animal Models to Genetic Studies

Authors: Frode, T. S.; Medeiros, Y. S.

Source: Current Pharmaceutical Design, Volume 11, Number 19, July 2005 , pp. 2515-2524(10)

Publisher: Bentham Science Publishers

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Abstract:

The recognition that asthma is an inflammatory disease opens a new field to find effective models for the evaluation and development of new drugs. In this scenario, many novel candidate molecules have been shown to work perfectly in animal models, but not in clinical studies. Ancillary models are reviewed in association with the findings obtained in either transgenic or knockout mice. In parallel, genetic studies in animal models and human populations have identified several genes that are asthma-related. Knowledge of these recent findings, in parallel with pharmacogenomic studies will be necessary to direct new strategies for the development of novel drugs to treat subgroups of patients with asthma.

Keywords: asthma; animal models; genetic studies

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1381612054367517

Affiliations: 1: Departamento de Analises Clinicas - CCS, Universidade Federal de Santa Catarina, Campus Universitario - Trindade, 88040-970, Florianopolis, SC, Brazil.

Publication date: 2005-07-01

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Current Pharmaceutical Design publishes timely in-depth reviews covering all aspects of current research in rational drug design. Each issue is devoted to a single major therapeutic area. A Guest Editor who is an acknowledged authority in a therapeutic field has solicits for each issue comprehensive and timely reviews from leading researchers in the pharmaceutical industry and academia.

Each thematic issue of Current Pharmaceutical Design covers all subject areas of major importance to modern drug design, including: medicinal chemistry, pharmacology, drug targets and disease mechanism.