Microcirculation of the Diabetic Foot

Authors: Dinh, T.; Veves, A.

Source: Current Pharmaceutical Design, Volume 11, Number 18, July 2005 , pp. 2301-2309(9)

Publisher: Bentham Science Publishers

Buy & download fulltext article:

Price: $63.10 plus tax (Refund Policy)

Abstract:

Studies over the last decade have revealed impairment of the microcirculation in the diabetic foot. Endothelial dysfunction along with derangements in numerous biochemical pathways has been implicated as causes of microcirculation impairment. Additionally, reduction or absence of the nerve-axon reflex renders the diabetic foot unable to mount a vasodilatory response under conditions of stress, such as injury or infection and makes it functionally ischemic even in the presence of satisfactory blood flow under normal conditions. Furthermore, these changes appear to be directly related to the presence of diabetic neuropathy. These alterations in the diabetic microcirculation may explain the poor wound healing commonly observed in diabetes.

Keywords: small vessel disease; femoro-popliteal bypass grafts; microcircuiation; basement membrane; non-diabetic foot; laser doppler flowmetry; Iontophoresis; flow video microscopy; endotheliumderived; relaxing factor (edrf)

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1381612054367328

Affiliations: 1: Microcirculation Lab., Palmer 317, Beth Israel Deaconess Medical Center, West Campus, One Deaconess Road, Boston, MA 02215, USA.

Publication date: 2005-07-01

More about this publication?

Current Pharmaceutical Design publishes timely in-depth reviews covering all aspects of current research in rational drug design. Each issue is devoted to a single major therapeutic area. A Guest Editor who is an acknowledged authority in a therapeutic field has solicits for each issue comprehensive and timely reviews from leading researchers in the pharmaceutical industry and academia.

Each thematic issue of Current Pharmaceutical Design covers all subject areas of major importance to modern drug design, including: medicinal chemistry, pharmacology, drug targets and disease mechanism.