Molecular Pathways Involved in Apoptotic Cell Death in the Injured Cochlea: Cues to Novel Therapeutic Strategies

Authors: Lallemend, F.; Lefebvre, P. P.; Hans, G.; Moonen, G.; Malgrange, B.

Source: Current Pharmaceutical Design, Volume 11, Number 17, July 2005 , pp. 2257-2275(19)

Publisher: Bentham Science Publishers

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Abstract:

Most hearing loss results from lesions of the sensory cells and/or neurons of the auditory portion of the inner ear. To date, only the cochlear implantation offers long-term hearing-aid benefit, but still with limited performance and expensive cost. While the underlying causes of deafness are not clear, the death or hair cells and/or neurons and the loss of neuronal contacts are key pathological features. Pinpointing molecular events that control cell death in the cochlea is critical for the development of new strategies to prevent and treat deafness, whether in combination or not with cochlear implant therapy.

Keywords: cochlea; cell death; ototoxicity; noise trauma; neuroprotection; trophic factors

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1381612054367346

Affiliations: 1: Research Center for Cellular and Molecular Neurobiology, University of Liege, 17 Place Delcour, B- 4020 Liege, Belgium.

Publication date: 2005-07-01

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