Inflammatory-Mediated Injury and Repair in the Traumatically Injured Spinal Cord
Authors: Jones, T. B.; McDaniel, E. E.; Popovich, P. G.
Source: Current Drug Metabolism, Volume 11, Number 10, April 2005 , pp. 1223-1236(14)
Publisher: Bentham Science Publishers
Abstract:
Spinal cord trauma activates the immune system and elicits leukocyte recruitment to the site of injury. This increase in immunological activity contributes to acute lesion expansion over a period of days to weeks following the initial trauma. At the same time, inflammatory cells and mediators facilitate endogenous repair processes such as axonal sprouting and remyelination. Thus, to be effective, therapies that target the immune system must limit the destructive effects of neutrophil, macrophage and lymphocyte activation, while simultaneously preserving their reparative functions.Keywords: inflammation; spinal cord injury; neuroprotection; immunology; pathology
Document Type: Review article
DOI: http://dx.doi.org/10.2174/1381612053507468
Affiliations: 1: Dept. of Molecular Virology, Immunology & Medical Genetics, 2078 Graves Hall, 333 W. 10th Ave.,Columbus, Ohio 43210.
Publication date: 2005-04-01
- Current Pharmaceutical Design publishes timely in-depth reviews covering all aspects of current research in rational drug design. Each issue is devoted to a single major therapeutic area. A Guest Editor who is an acknowledged authority in a therapeutic field has solicits for each issue comprehensive and timely reviews from leading researchers in the pharmaceutical industry and academia.
Each thematic issue of Current Pharmaceutical Design covers all subject areas of major importance to modern drug design, including: medicinal chemistry, pharmacology, drug targets and disease mechanism.
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- In this Subject: Pharmacology
- By this author: Jones, T. B. ; McDaniel, E. E. ; Popovich, P. G.

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