Inflammatory-Mediated Injury and Repair in the Traumatically Injured Spinal Cord

Authors: Jones, T. B.¹; McDaniel, E. E.¹; Popovich, P. G.¹

Source: Current Pharmaceutical Design, Volume 11, Number 10, April 2005 , pp. 1223-1236(14)

Publisher: Bentham Science Publishers

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Abstract:

Spinal cord trauma activates the immune system and elicits leukocyte recruitment to the site of injury. This increase in immunological activity contributes to acute lesion expansion over a period of days to weeks following the initial trauma. At the same time, inflammatory cells and mediators facilitate endogenous repair processes such as axonal sprouting and remyelination. Thus, to be effective, therapies that target the immune system must limit the destructive effects of neutrophil, macrophage and lymphocyte activation, while simultaneously preserving their reparative functions.

Keywords: inflammation; spinal cord injury; neuroprotection; immunology; pathology

Document Type: Review article

DOI: 10.2174/1381612053507468

Affiliations: 1: Dept. of Molecular Virology, Immunology & Medical Genetics, 2078 Graves Hall, 333 W. 10th Ave.,Columbus, Ohio 43210.

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