Author: Fackelmayer, Frank O.

Source: Current Pharmaceutical Design, Volume 10, Number 23, September 2004 , pp. 2851-2860(10)

Publisher: Bentham Science Publishers

Abstract:

The architecture of the cell nucleus has long been a matter of debate, and is still not completely understood yet. However, much progress has been made in the last few years, gradually unraveling nuclear infrastructure and its importance of the regulation of key genetic events. It is now established that the readout of genetic information and its faithful duplication are not only affected by regulatory sequences in the genome, but also by their localization in the threedimensional context and their relative position to functional subcompartments in the nucleus. Understanding how nuclear architecture and function are related and depend on each other has great potential to open up novel ways for the development of therapeutic agents. It is the purpose of this review to shed light on the role of nuclear architecture in regulating gene expression, and suggest that interfering with specific protein-protein interactions of transcription factors might provide new approaches to drug development.

Keywords: nuclear matrix; transcription factor; hormone receptor; gene expression

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1381612043383557

Affiliations: 1: Dept. of Molecular Cell Biology, Heinrich-Pette-Institute, Martinistrasse 52, 20251 Hamburg, Germany

Publication date: 2004-09-01

More about this publication?

• Current Pharmaceutical Design publishes timely in-depth reviews covering all aspects of current research in rational drug design. Each issue is devoted to a single major therapeutic area. A Guest Editor who is an acknowledged authority in a therapeutic field has solicits for each issue comprehensive and timely reviews from leading researchers in the pharmaceutical industry and academia.
  
  Each thematic issue of Current Pharmaceutical Design covers all subject areas of major importance to modern drug design, including: medicinal chemistry, pharmacology, drug targets and disease mechanism.

Related content

• In this: publication
• By this: publisher
• In this Subject: Pharmacology
• By this author: Fackelmayer, Frank O.

Website © Publishing Technology. Article copyright remains with the publisher, society or author(s) as specified within the article.

• Terms and conditions
• Privacy policy
• Information for advertisers