Authors: Bacher, Susanne; Schmitz, M. L.

Source: Current Pharmaceutical Design, Volume 10, Number 23, September 2004 , pp. 2827-2837(11)

Publisher: Bentham Science Publishers

Abstract:

A battery of proinflammatory agents triggers the activation of NF-B. This inducible transcription factor participates in the expression of an exceptionally large number of target genes, many of them contributing to the regulation of innate and adaptive immunity. Since some target genes also function as NF-B activators, activation of this transcription factor allows the establishment of a signal amplification loop. Dysregulation of the NF-B system and hyperactivated expression of inflammatory mediators are often found in association with some autoimmune diseases, which occur upon mounting of the adaptive immune response against self-antigens. In this review we summarize the relevance of aberrant NF-B signaling for the development and perpetuation of some autoimmune diseases such as rheumatoid arthritis, diabetes mellitus type 1 and Crohn's disease. The assets and drawbacks of systemic or cell-type specific NF-kB inhibitors and their potential use in therapy of autoimmune diseases are critically discussed.

Keywords: ikk; autoimmune disease; inflammation; crohns disease; rheumatoid arthritis

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1381612043383584

Affiliations: 1: University of Bern, Department of Chemistry and Biochemistry, Freiestr. 3, CH-3012 Bern (Switzerland)

Publication date: 2004-09-01

More about this publication?

• Current Pharmaceutical Design publishes timely in-depth reviews covering all aspects of current research in rational drug design. Each issue is devoted to a single major therapeutic area. A Guest Editor who is an acknowledged authority in a therapeutic field has solicits for each issue comprehensive and timely reviews from leading researchers in the pharmaceutical industry and academia.
  
  Each thematic issue of Current Pharmaceutical Design covers all subject areas of major importance to modern drug design, including: medicinal chemistry, pharmacology, drug targets and disease mechanism.

Related content

• In this: publication
• By this: publisher
• In this Subject: Pharmacology
• By this author: Bacher, Susanne ;  Schmitz, M. L.

Website © Publishing Technology. Article copyright remains with the publisher, society or author(s) as specified within the article.

• Terms and conditions
• Privacy policy
• Information for advertisers