Authors: Rege, Yashraj D.; Rangnekar, Vivek M.

Source: Current Pharmaceutical Design, Volume 10, Number 5, February 2004 , pp. 523-530(8)

Publisher: Bentham Science Publishers

Abstract:

Prostate cancer is the most frequently diagnosed disease in American men today and the second leading cause of death among them. Transformation and progression towards malignancy in prostate cancer is dependant on the inability of the prostatic epithelial cells to undergo apoptosis rather than on the regulation of proliferation. Molecular targeting of inadequacies in this process of suppression of apoptosis could prove to be of great therapeutic importance for prostate cancer patients. Existence of tissue specific promoters to aid in the delivery of genes with therapeutic potential makes molecular therapy an attractive option. This review discusses salient features of molecules such as, Bcl-2, Bcl-XL, NF-kB, Akt, PTEN and Par-4 that play a significant role in the regulation of prostate cancer and focuses on the prospects of effectively utilizing their potential for the therapy of hormone-sensitive and hormone-resistant prostate cancer.

Keywords: par-4; prostate cancer; genes; apoptosis; molecular therapy

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1381612043453234

Affiliations: 1: Department of Radiation Medicine, University of Kentucky, Combs Research Building, Rm. 303, 800 Rose Street, Lexington, KY 40536, USA.

Publication date: 2004-02-01

More about this publication?

• Current Pharmaceutical Design publishes timely in-depth reviews covering all aspects of current research in rational drug design. Each issue is devoted to a single major therapeutic area. A Guest Editor who is an acknowledged authority in a therapeutic field has solicits for each issue comprehensive and timely reviews from leading researchers in the pharmaceutical industry and academia.
  
  Each thematic issue of Current Pharmaceutical Design covers all subject areas of major importance to modern drug design, including: medicinal chemistry, pharmacology, drug targets and disease mechanism.

Related content

• In this: publication
• By this: publisher
• In this Subject: Pharmacology
• By this author: Rege, Yashraj D. ;  Rangnekar, Vivek M.

Website © Publishing Technology. Article copyright remains with the publisher, society or author(s) as specified within the article.

• Terms and conditions
• Privacy policy
• Information for advertisers