Delta Opioid Peptides Derived from Plant Proteins
Authors: Yoshikawa, M.; Takahashi, M.; Yang, S.
Source: Current Pharmaceutical Design, Volume 9, Number 16, June 2003 , pp. 1325-1330(6)
Publisher: Bentham Science Publishers
Abstract:
Opioid peptides showing selectivity for d receptor have been isolated from enzymatic digests of plant proteins. Five peptides were derived from wheat gluten, and named gluten exorphins A5, A4, B5, B4 and C. Two opioid peptides were also released from spinach ribulosebisphosphate- carboxylase / oxygenase (Rubisco), and named rubiscolins-5 and -6. Among them, gluten exorphin 5A (Gly-Tyr-Tyr-Pro-Thr) and rubiscolin-6 (Tyr-Pro-Leu-Asp-Leu-Phe) improved learning performance in step-through type passive avoidance test after post-training oral administration in mice at doses of 300 mg / kg and 100 mg / kg, respectively, which are smaller than those required for antinociceptive activity.Keywords: opioid peptide; gluten exorphin; rubisco; antinociception; learning; memory; anxiolytic; antidepressant
Document Type: Review article
DOI: http://dx.doi.org/10.2174/1381612033454838
Publication date: 2003-06-01
- Current Pharmaceutical Design publishes timely in-depth reviews covering all aspects of current research in rational drug design. Each issue is devoted to a single major therapeutic area. A Guest Editor who is an acknowledged authority in a therapeutic field has solicits for each issue comprehensive and timely reviews from leading researchers in the pharmaceutical industry and academia.
Each thematic issue of Current Pharmaceutical Design covers all subject areas of major importance to modern drug design, including: medicinal chemistry, pharmacology, drug targets and disease mechanism.
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- In this Subject: Pharmacology
- By this author: Yoshikawa, M. ; Takahashi, M. ; Yang, S.

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