Insulin and the Blood-Brain Barrier

Authors: Woods, S.C.; Seeley, R.J.; Baskin, D.G.; Schwartz, M.W.

Source: Current Pharmaceutical Design, Volume 9, Number 10, April 2003 , pp. 795-800(6)

Publisher: Bentham Science Publishers

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Abstract:

Although several possible mechanisms exist by which the pancreatic hormone, insulin, could enter the brain from the blood, most evidence suggests that the majority of it enters primarily by a receptor-mediated transport process. Many factors influence the rate of entry, including fasting and refeeding and several pathological conditions. Within the brain insulin acts on specific receptors to influence a number of behaviors, and especially caloric homeostasis and cognition.

Keywords: Insulin; Blood-Brain Barrier; homeostasis

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1381612033455323

Publication date: 2003-04-01

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Each thematic issue of Current Pharmaceutical Design covers all subject areas of major importance to modern drug design, including: medicinal chemistry, pharmacology, drug targets and disease mechanism.