Cationic Peptides: Distribution and Mechanisms of Resistance

Authors: Devine, D.A.; Hancock, R.E.W.

Source: Current Pharmaceutical Design, Volume 8, Number 9, 1 April 2002 , pp. 703-714(12)

Publisher: Bentham Science Publishers

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Abstract:

Cationic antimicrobial peptides are observed throughout nature. In mammals they are observed both at epithelial surfaces and within the granules of phagocytic cells. They are an important component of innate defences, since in addition to their ability to kill microorganisms, they are able to modulate inflammatory responses. With respect to their ability to kill bacteria, it is very difficult to isolate resistant mutants. However there are a few known mechanisms of intrinsic resistance, including PhoPQ-dependent and other alterations in lipopolysaccharide structure that influence self promoted uptake, and protease-mediated resistance.

Keywords: Cationic Peptides; Cationic antimicrobial peptides; antimicrobial peptides; cationic abtimicrobial peptides; phopq; phopphoq regulon; burkholderia cepacia; proteases

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1381612023395501

Publication date: 2002-04-01

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Current Pharmaceutical Design publishes timely in-depth reviews covering all aspects of current research in rational drug design. Each issue is devoted to a single major therapeutic area. A Guest Editor who is an acknowledged authority in a therapeutic field has solicits for each issue comprehensive and timely reviews from leading researchers in the pharmaceutical industry and academia.

Each thematic issue of Current Pharmaceutical Design covers all subject areas of major importance to modern drug design, including: medicinal chemistry, pharmacology, drug targets and disease mechanism.