The Role of Protease Inhibition with Emphasis on the Effects of Inflammation and Vascular Immune Phenomena

Authors: Bilfinger, T.V.; Stefano, G.B.

Source: Current Pharmaceutical Design, Volume 8, Number 7, 1 March 2002 , pp. 505-509(5)

Publisher: Bentham Science Publishers

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Abstract:

This review discusses the role of protease inhibition with emphasis on the effects of inflammation and vascular immune phenomena in non-immunocompromised hosts. A vast body of knowledge elucidating the role of protease inhibition and hemostasis has accumulated in recent years. The two subjects are intimately linked, but the focus of this review is limited to the anti-inflammatory effects of protease inhibitors. In light of the particular expertise of the present authors, this review will focus on human studies and often cite work related to open-heart surgery, since in recent years this is the area in which a large effort has been concentrated worldwide.

Keywords: protease inhibition; inflammation; protease inhibitors; Inflammatory processes

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1381612023395763

Publication date: 2002-03-01

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Current Pharmaceutical Design publishes timely in-depth reviews covering all aspects of current research in rational drug design. Each issue is devoted to a single major therapeutic area. A Guest Editor who is an acknowledged authority in a therapeutic field has solicits for each issue comprehensive and timely reviews from leading researchers in the pharmaceutical industry and academia.

Each thematic issue of Current Pharmaceutical Design covers all subject areas of major importance to modern drug design, including: medicinal chemistry, pharmacology, drug targets and disease mechanism.