A Review of Molecular Modeling Approaches to Pharmacophore Models and Structure-Activity Relationships of Ion Channel Modulators in CNS

Authors: Li, Y.; Harte, W.E.

Source: Current Pharmaceutical Design, Volume 8, Number 2, 1 January 2002 , pp. 99-110(12)

Publisher: Bentham Science Publishers

Key:

- Free Content

- New Content

- Subscribed Content

- Free Trial Content

Abstract:

Through pharmacophore models and providing quantitative analysis of structure-activity relationships (QSAR), molecular modeling techniques can be useful tools to study the interactions of ion channels and their modulators. The present review focuses on molecular modeling approaches that defined pharmacophore models of ion channel modulators in the CNS. The commonality and subtlety of the pharmacophore models of various ion channel modulators are discussed which can be used as a framework for the design of ion channel modulators.

Keywords: Ion Channel Modulators in CNS; Pharmacophore and QSAR Modeling; NAChR; 5-HT3

Document Type: Review article

DOI: 10.2174/1381612023396546

The full text electronic article is available for purchase. You will be able to download the full text electronic article after payment.

$55.10 plus tax Refund Policy