Instrumentation and Methodology for Quantitative Pre-Clinical Imaging Studies

Authors: Meikle, S.R.; Eberl, S.; Iida, H.

Source: Current Pharmaceutical Design, Volume 7, Number 18, 1 December 2001 , pp. 1945-1966(22)

Publisher: Bentham Science Publishers

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Abstract:

Radiotracer imaging studies performed on animals have the potential to play a major role in pharmaceutical development, pharmacology studies and basic biochemistry research. Recent developments in instrumentation and imaging metho- dology make it possible to image and quantify the kinetics of radiolabelled pharmaceuticals in a wide range of animal models from rodents to non-human primates. This article reviews the developments which have led to the current state-of-the-art, including advances in detector technologies, image reconstruction and tracer kinetic modelling. The practical issues specific to animal imaging studies are also discussed. With appropriate instrumentation and rigorous methodology, quantitative pre-clinical imaging has an important role to play in drug development.

Keywords: animal imaging; tracer kinetics; positron emission tomography; single photon emission tomography; spect

Document Type: Review article

DOI: 10.2174/1381612013396961

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