DNA-Photocleavage Agents

Authors: Da Ros, T.; Spalluto, G.; Boutorine, A.S.; Bensasson, R.V.; Prato, M.

Source: Current Pharmaceutical Design, Volume 7, Number 17, 1 November 2001 , pp. 1781-1821(41)

Publisher: Bentham Science Publishers

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Abstract:

This review describes recent advances in the development of DNA-photocleavage agents. Major mechanisms of photosensitized DNA photocleavage are presented and the most popular categories of compounds are considered, which include metal complexes and many organic functional derivatives. DNA-targeted conjugates of photosensitizers are also described and discussed.

Keywords: DNA-Photocleavage Agents; Anthraquinones; Naphthalimides; Anthryl Derivatives; Benzotriazole Derivatives; Quinolines; Quinoxalines; Naphthyridines; Fluoroquinolones; Diazo Derivatives

Document Type: Review article

DOI: 10.2174/1381612013397140

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