DNA-Photocleavage Agents

Authors: Da Ros, T.; Spalluto, G.; Boutorine, A.S.; Bensasson, R.V.; Prato, M.

Source: Current Pharmaceutical Design, Volume 7, Number 17, 1 November 2001 , pp. 1781-1821(41)

Publisher: Bentham Science Publishers

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Abstract:

This review describes recent advances in the development of DNA-photocleavage agents. Major mechanisms of photosensitized DNA photocleavage are presented and the most popular categories of compounds are considered, which include metal complexes and many organic functional derivatives. DNA-targeted conjugates of photosensitizers are also described and discussed.

Keywords: DNA-Photocleavage Agents; Anthraquinones; Naphthalimides; Anthryl Derivatives; Benzotriazole Derivatives; Quinolines; Quinoxalines; Naphthyridines; Fluoroquinolones; Diazo Derivatives

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1381612013397140

Publication date: 2001-11-01

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Current Pharmaceutical Design publishes timely in-depth reviews covering all aspects of current research in rational drug design. Each issue is devoted to a single major therapeutic area. A Guest Editor who is an acknowledged authority in a therapeutic field has solicits for each issue comprehensive and timely reviews from leading researchers in the pharmaceutical industry and academia.

Each thematic issue of Current Pharmaceutical Design covers all subject areas of major importance to modern drug design, including: medicinal chemistry, pharmacology, drug targets and disease mechanism.