Authors: Fahy, J.; Hill, B.T.

Source: Current Drug Metabolism, Volume 7, Number 13, 1 September 2001 , pp. 1297-1301(5)

Publisher: Bentham Science Publishers

Abstract:

Besides the many recognised compounds described and detailed in the present issue including the Vinca alkaloids, the taxanes, certain cryptophycines, epothilones and eleutherobines, several new products interacting with tubulin are identified regularly in the literature. These products may have been isolated from natural sources (plants, marine organisms, bacteria), but also more recently combinatorial, or at least automatised chemistry, has provided new families of small molecules, which on occasions have been found by High Throughput Screening directed against tubulin as a specific target. A recent review has listed more than one hundred of such derivatives [1]. Certain of these are in an advanced stage of pharmaceutical development, as reviewed by Li et al. [2] and von Angerer [3]. From a mechanistic point of view, these newer products may be classified into one of three main families, although exceptions to this rule are now also being reported on. microtubule stabilising compounds, Vinca alkaloid site interacting agents, colchicine site binders.

This brief final contribution to this volume will focus only on the newly identified products for which active pharmaceutical development has been reported on during the last three years.

Keywords: Cryptophycines; Epothilones; Eleutherobines; vinflunine

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1381612013397447

Publication date: 2001-09-01

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• Current Pharmaceutical Design publishes timely in-depth reviews covering all aspects of current research in rational drug design. Each issue is devoted to a single major therapeutic area. A Guest Editor who is an acknowledged authority in a therapeutic field has solicits for each issue comprehensive and timely reviews from leading researchers in the pharmaceutical industry and academia.
  
  Each thematic issue of Current Pharmaceutical Design covers all subject areas of major importance to modern drug design, including: medicinal chemistry, pharmacology, drug targets and disease mechanism.

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