General and Recent Aspects of the Chemistry and Structure Activity Relationships of Taxoids

Author: Gueritte, F.

Source: Current Pharmaceutical Design, Volume 7, Number 13, 1 September 2001 , pp. 1229-1249(21)

Publisher: Bentham Science Publishers

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Abstract:

The antimitotic agents of the Taxoid series are important substances as anticancer drugs. The efficacy of paclitaxel (Taxol) and docetaxel (Taxotere) has been well demonstrated in the treatment of breast, ovarian and lung cancers. Although these drugs have brought benefits in cancer chemotherapy, they unfortunately possess some disadvantages due to their inefficacy on certain resistant cancers, and due to their toxic side effects. For these reasons, the synthesis of new taxoids with improved biological activity is still an important research area. This review while covering general aspects of taxoid chemistry focuses on recent developments in this area especially those contributing to the improved availability of antimitotic taxoids. Studies of structure-activity relationships are also described.

Keywords: Taxoids; Paclitaxel; Docetaxel; lung cancers; taxoid chemistry; Taxus brevifolia; Taxus baccata; Taxus wallichiana; Taxus Canadensis; Deoxybaccatin

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1381612013397429

Publication date: 2001-09-01

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Current Pharmaceutical Design publishes timely in-depth reviews covering all aspects of current research in rational drug design. Each issue is devoted to a single major therapeutic area. A Guest Editor who is an acknowledged authority in a therapeutic field has solicits for each issue comprehensive and timely reviews from leading researchers in the pharmaceutical industry and academia.

Each thematic issue of Current Pharmaceutical Design covers all subject areas of major importance to modern drug design, including: medicinal chemistry, pharmacology, drug targets and disease mechanism.