Specific Molecular Targets to Control Tropical Diseases

Author: Rodriguez, J.B.

Source: Current Pharmaceutical Design, Volume 7, Number 12, 1 August 2001 , pp. 1105-1116(12)

Publisher: Bentham Science Publishers

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Abstract:

Chagas disease or American trypanosomiasis is considered by the Word Health Organization to be one of the important tropical parasitic diseases worldwide together with malaria and schistosomiasis. The etiologic agent of this illness is the kinetoplastid protozoon Trypanosoma cruzi. The present chemotherapy for the treatment of Chagas disease remains unsolved. The drugs currently in use are old, ineffective and toxic. Bearing in mind the metabolic differences between the parasite and the mammalian host, some attractive interesting molecular targets for drug design are presented.

Keywords: Molecular Targets; Tropical Diseases; Chagas disease; Malaria; schistosomiasis; Trypanosoma cruzi; Inhibitors; 4-PhenoxyphenoxyethylAllyl Ether; Tetrahydro-2H-pyran- 2-yl Ether; Potent Sulfur-containing Derivatives

Document Type: Review article

DOI: 10.2174/1381612013397555

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