Author: Ozturk, Y.

Source: Current Drug Metabolism, Volume 7, Number 2, 1 January 2001 , pp. 135-161(27)

Publisher: Bentham Science Publishers

Abstract:

Plasma kinins are a family of peptides which play an important role in a variety of pathophysiological conditions. As a consequence of the progress in the area of kinin receptors, specific kinin receptor antagonists will be available in near future in order to provide more selective therapeutic modalities for the treatment of diseases such as asthma, cardiovascular diseases, inflammation, pain, etc.

Although the initial observation leading to dicovery of kinins has been performed in 1909, important progress on the development of specific kinin receptor antagonists has been made in last two decades. This review emphesizes the physiological functions of kinins along with their receptor subtypes and post-receptor events in the cellular signaling. In this article, the latest developments in the kinin receptor antagonists including nonpeptide ones have been reviewed

Keywords: Kinin Receptors; Novel Therapeutic agents; Hypotensive smooth muscle; Bradykinin; Kallikrein kinin system; Positive intropic effect; Vasopressin induced; Myogenic activities; Receptor mediated contractions; Intrinsic cholinergic; Tumour necrosis factor; Endothelium dependent relaxing; Mitogenic effects; BK receptors; Platelet derived growth; L8 rat skeletal myoblasts; Denervated tongue muscle; Electrophsiological studies; Chemokine induced hyperalgesia; enterochromaffin cells; Neutral endopeptidase; Cardiomyocytes cocultured; Immunohistochemical study; Inositolphosphate; Signal Transduction; Antibradykinin

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1381612013398338

Publication date: 2001-01-01

More about this publication?

• Current Pharmaceutical Design publishes timely in-depth reviews covering all aspects of current research in rational drug design. Each issue is devoted to a single major therapeutic area. A Guest Editor who is an acknowledged authority in a therapeutic field has solicits for each issue comprehensive and timely reviews from leading researchers in the pharmaceutical industry and academia.
  
  Each thematic issue of Current Pharmaceutical Design covers all subject areas of major importance to modern drug design, including: medicinal chemistry, pharmacology, drug targets and disease mechanism.

Related content

• In this: publication
• By this: publisher
• In this Subject: Pharmacology
• By this author: Ozturk, Y.

Website © Publishing Technology. Article copyright remains with the publisher, society or author(s) as specified within the article.

• Terms and conditions
• Privacy policy
• Information for advertisers