Authors: Illidge, T.M.; Brock, S.

Source: Current Pharmaceutical Design, Volume 6, Number 14, 1 September 2000 , pp. 1399-1418(20)

Publisher: Bentham Science Publishers

Abstract:

After years of pre-clinical and clinical testing monoclonal antibodies (mAbs) finally offer new therapeutic choices for patients with haematological and solid malignancies both as unconjugated antibody and as vectors to target radionuclides in radioimmunotherapy (RIT). In recent years some of the most exciting clinical data have come from the use of RIT in the treatment of lymphoma and haematological malignancies and it would now appear highly likely that RIT will play a major role in the treatment strategies for these diseases. For the solid tumours there has also been considerable progress with RIT and mAbs have become a component of treatment protocols for breast cancer. This review highlights the important recent clinical progress that has been made with clinical RIT and provides some new insights into the important mechanisms of action of RIT in haematological malignancies.

Keywords: Target radiotherapy; monoclonal antibodies (mAbs); Radioimmunotherpy (RIT); Haematological malignancies; ADCC; Antibodies; Tumour nodules; HAMA response; Immunosuppression; Cyclosporin; Deoxysperualin; The Radioisotope; Radioimmunoglobulin; Normal tissue toxicity; Dosimetry; MIRD; Non myeloablative therapy in lymphoma; CD20 antibodies; Phase II pivotal; Complete response; Maximum Tolerated Dose; Immunoglobulin idiotype; IDEC Y2B8; Solid tumours

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1381612003399257

Publication date: 2000-09-01

More about this publication?

• Current Pharmaceutical Design publishes timely in-depth reviews covering all aspects of current research in rational drug design. Each issue is devoted to a single major therapeutic area. A Guest Editor who is an acknowledged authority in a therapeutic field has solicits for each issue comprehensive and timely reviews from leading researchers in the pharmaceutical industry and academia.
  
  Each thematic issue of Current Pharmaceutical Design covers all subject areas of major importance to modern drug design, including: medicinal chemistry, pharmacology, drug targets and disease mechanism.

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