Recent Developments in Tritium Incorporation for Radiotracer Studies

Authors: Saljoughian, M.; Williams, P.G.

Source: Current Pharmaceutical Design, Volume 6, Number 10, 1 July 2000 , pp. 1029-1056(28)

Publisher: Bentham Science Publishers

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Abstract:

The essential nature of rapid radiotracer synthesis very early in drug discovery programs has driven the need for better and more varied tritium incorporation methods. This review presents a summary of recent advances for tritium introduction via tritiated water, tritium gas, complex tritides, and a range of recently improved tritiation reagents. Access to a wider range of tritiated reagents (for tritioacetylation, tritioformylation, methylation, etc.) and commercial manifolds for the transfer and use of tritium gas is also discussed.

Keywords: Radiotracer studies; HTO; Heptafluorobutyric; HFBA; Levamisole; m Aminolevamisole; Tritide reagents; Lithium tritide; Lithium supertritide; Lithium aluminum tritide; Lithium selectride; Lithium trimethoxyborotritide; Tritiated methylborane; Lithium borotritide; Tritiated schwartz reagent; Tritiodehalogenation; Tritiodeoxygenation; Tritiodenitration; Tritiodeamination; Intramolecular hydrogen transfer; Tritiated methylene diiodide; Tritiated diimide; Base induced tritiodesilylation; Fluoride induced tritiodesilylation

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1381612003399969

Publication date: 2000-07-01

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Current Pharmaceutical Design publishes timely in-depth reviews covering all aspects of current research in rational drug design. Each issue is devoted to a single major therapeutic area. A Guest Editor who is an acknowledged authority in a therapeutic field has solicits for each issue comprehensive and timely reviews from leading researchers in the pharmaceutical industry and academia.

Each thematic issue of Current Pharmaceutical Design covers all subject areas of major importance to modern drug design, including: medicinal chemistry, pharmacology, drug targets and disease mechanism.