Recent Developments in Tritium Incorporation for Radiotracer Studies

Authors: Saljoughian, M.; Williams, P.G.

Source: Current Pharmaceutical Design, Volume 6, Number 10, 1 July 2000 , pp. 1029-1056(28)

Publisher: Bentham Science Publishers

Key:

- Free Content

- New Content

- Subscribed Content

- Free Trial Content

Abstract:

The essential nature of rapid radiotracer synthesis very early in drug discovery programs has driven the need for better and more varied tritium incorporation methods. This review presents a summary of recent advances for tritium introduction via tritiated water, tritium gas, complex tritides, and a range of recently improved tritiation reagents. Access to a wider range of tritiated reagents (for tritioacetylation, tritioformylation, methylation, etc.) and commercial manifolds for the transfer and use of tritium gas is also discussed.

Keywords: Radiotracer studies; HTO; Heptafluorobutyric; HFBA; Levamisole; m Aminolevamisole; Tritide reagents; Lithium tritide; Lithium supertritide; Lithium aluminum tritide; Lithium selectride; Lithium trimethoxyborotritide; Tritiated methylborane; Lithium borotritide; Tritiated schwartz reagent; Tritiodehalogenation; Tritiodeoxygenation; Tritiodenitration; Tritiodeamination; Intramolecular hydrogen transfer; Tritiated methylene diiodide; Tritiated diimide; Base induced tritiodesilylation; Fluoride induced tritiodesilylation