Authors: Morton, L.D.; Pellock, J.M.

Source: Current Pharmaceutical Design, Volume 6, Number 8, 1 May 2000 , pp. 879-900(22)

Publisher: Bentham Science Publishers

Abstract:

Seizures have a variety of etiologies and manifestations. Descriptions of various epiletic seizures as well as electroencephalographic findings have led to a unifying international classification of epileptic seizures and epilepsy syndromes. The development of this classification system and the emergence of several new antiepiletic drugs have led to progress in the refractory pediatric patient particularly disorders which are traditionally difficult to treat such as infantile spasms and the Lennox-Gastaut Syndrome. However, there is limited data regarding optimal use in children.

The childhood epilepsy syndromes are reviewed as well as the newer antiepileptic drug treatments felbamate, gabapentin, lamotrigine, levetiracetam, oxcarbazepine, tiagabine, topiramate, and zonisamide. Efficacy data and toxicity are discussed from both the adult, and when available, pediatric data.

Keywords: Childhood epilepsy; Epileptic syndromes; Seizures; Felbamate; Gabapentin; Lamotrigine; Levetiracetam; Oxcarbazepine; Tiagabine; Topiramate; Zonisamide; Electroencephalographic; Antiepilepsy drugs; Neonatal syndromes; Symptomatic; Cryptogenic; Adolescence; Lennox gastaut syndrome; Partial Seizures; Kojenikows syndrome; Rasmussens syndrome; Landau kleffner syndrome; Generalized tonic clonic seizures; Gabapentin

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1381612003400281

Publication date: 2000-05-01

More about this publication?

• Current Pharmaceutical Design publishes timely in-depth reviews covering all aspects of current research in rational drug design. Each issue is devoted to a single major therapeutic area. A Guest Editor who is an acknowledged authority in a therapeutic field has solicits for each issue comprehensive and timely reviews from leading researchers in the pharmaceutical industry and academia.
  
  Each thematic issue of Current Pharmaceutical Design covers all subject areas of major importance to modern drug design, including: medicinal chemistry, pharmacology, drug targets and disease mechanism.

Related content

• In this: publication
• By this: publisher
• In this Subject: Pharmacology
• By this author: Morton, L.D. ;  Pellock, J.M.

Website © Publishing Technology. Article copyright remains with the publisher, society or author(s) as specified within the article.

• Terms and conditions
• Privacy policy
• Information for advertisers