Authors: Hogaboam, C.M.; Bone-Larson, C.; Matsukawa, A.; Steinhauser, M.L.; Blease, K.; Lukacs, N.W.; Kunkel, S.L.

Source: Current Pharmaceutical Design, Volume 6, Number 6, 1 April 2000 , pp. 651-663(13)

Publisher: Bentham Science Publishers

Abstract:

Chemokines are involved in a number of pathological processes, and therefore represent important targets. However, it has also become apparent that chemokines have exciting therapeutic applications in inflammatory, infectious and cancer-related diseases. The following review will highlight the application of novel therapies including viral-encoded, recombinant, and genetically engineered chemokines to a number of diseases or disorders. Advances in the application of novel chemokine delivery procedures both at the research bench and the clinical bedside will also be discussed. Overall, the utilization of chemokines to prevent and treat disease has tremendous potential.

Keywords: Chemokomes; chemoattractant proteins MCP; rantes; macrophage Inflammatory; Glu Leu Arg; Oncogene; monokine; interferon gamma; Viral; Kaposi sarcoma associated herpesvirus; T Cell; Dendritic cell movement; EB11 ligand chemokine; immune responses; Pseudomonas aeruginosa; Salmonella typhimurium; ELR CXC; Liver Regeneration; Lymphoid tissue; Wound Healing; cancer; HIV infection; Sepsis; Renal glomerulonephritis; Mycobacterium; Pulmonary granulomatous

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1381612003400605

Publication date: 2000-04-01

More about this publication?

• Current Pharmaceutical Design publishes timely in-depth reviews covering all aspects of current research in rational drug design. Each issue is devoted to a single major therapeutic area. A Guest Editor who is an acknowledged authority in a therapeutic field has solicits for each issue comprehensive and timely reviews from leading researchers in the pharmaceutical industry and academia.
  
  Each thematic issue of Current Pharmaceutical Design covers all subject areas of major importance to modern drug design, including: medicinal chemistry, pharmacology, drug targets and disease mechanism.

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