Therapeutic Use of Chemokines

Authors: Hogaboam, C.M.; Bone-Larson, C.; Matsukawa, A.; Steinhauser, M.L.; Blease, K.; Lukacs, N.W.; Kunkel, S.L.

Source: Current Pharmaceutical Design, Volume 6, Number 6, 1 April 2000 , pp. 651-663(13)

Publisher: Bentham Science Publishers

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Abstract:

Chemokines are involved in a number of pathological processes, and therefore represent important targets. However, it has also become apparent that chemokines have exciting therapeutic applications in inflammatory, infectious and cancer-related diseases. The following review will highlight the application of novel therapies including viral-encoded, recombinant, and genetically engineered chemokines to a number of diseases or disorders. Advances in the application of novel chemokine delivery procedures both at the research bench and the clinical bedside will also be discussed. Overall, the utilization of chemokines to prevent and treat disease has tremendous potential.

Keywords: Chemokomes; chemoattractant proteins MCP; rantes; macrophage Inflammatory; Glu Leu Arg; Oncogene; monokine; interferon gamma; Viral; Kaposi sarcoma associated herpesvirus; T Cell; Dendritic cell movement; EB11 ligand chemokine; immune responses; Pseudomonas aeruginosa; Salmonella typhimurium; ELR CXC; Liver Regeneration; Lymphoid tissue; Wound Healing; cancer; HIV infection; Sepsis; Renal glomerulonephritis; Mycobacterium; Pulmonary granulomatous