Author: Standiford, T.J.

Source: Current Pharmaceutical Design, Volume 6, Number 6, 1 April 2000 , pp. 633-649(17)

Publisher: Bentham Science Publishers

Abstract:

Cytokines are critical mediators of protective host responses, including defense against microbial invasion and tumorigenesis. However, the production of specific proinflammatory cytokines must be tightly regulated and compartmentalized to prevent the overzealous expression of these molecules that can culminate in unabated inflammation and tissue injury. Cytokine production and/or biologic effects can be inhibited by a variety of endogenous molecules, including anti-inflammatory cytokines, soluble cytokine receptors, and receptor antagonist proteins. Additionally, synthetic molecules have been constructed to selectively block the synthesis, post-translation processing, or receptor binding of proinflammatory cytokines. Relevant anti-inflammatory cytokines and cytokine inhibitors (both endogenous and synthetic) will be the subject of this review, with a particular emphasis on those anti-inflammatory cytokines and cytokine inhibitors that have been used experimentally or clinically in the treatment of diseases that are believed to be mediated by excessive proinflammatory cytokine responses.

Keywords: Antiinflammatory Cytokines; Antagonists; Microbial Invasion; tumorigenesis; receptor; proteins; endogenous synthetic; Regulation; Sepsis syndrome; rhematoid arthritis RA; Interleukin 4 IL4; autoimmune disease; Proinflammatory; Necrosis Factor; Pathogenesis; Blockade; Chemokines; Transcriptional factor Inhibitors

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1381612003400533

Publication date: 2000-04-01

More about this publication?

• Current Pharmaceutical Design publishes timely in-depth reviews covering all aspects of current research in rational drug design. Each issue is devoted to a single major therapeutic area. A Guest Editor who is an acknowledged authority in a therapeutic field has solicits for each issue comprehensive and timely reviews from leading researchers in the pharmaceutical industry and academia.
  
  Each thematic issue of Current Pharmaceutical Design covers all subject areas of major importance to modern drug design, including: medicinal chemistry, pharmacology, drug targets and disease mechanism.

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