Authors: Hantz, O.; Kraus, J-L.; Zoulim, F.

Source: Current Pharmaceutical Design, Volume 6, Number 5, 1 March 2000 , pp. 503-523(21)

Publisher: Bentham Science Publishers

Abstract:

Antiviral therapy of chronic hepatitis B remains a major clinical problem worldwide. The design of new nucleoside analogs that inhibit hepatitis B virus (HBV) replication allowed their evaluation in in vitro and in vivo experimental models of HBV infection. This research has led to the discovery of the anti-HBV activity of lamivudine and its approval for the therapy of chronic hepatitis B. However, due to the development of viral resistance, strategies based on the combination of new inhibitors of HBV replication with immune modulatory approaches are urgently required.

Keywords: Hepatitis B Virus Inhibitors; Antiviral Therapy; Anti HBV; Infection; Lamivudine; activity; Drug Design; Nucleoside analogs; Pronucleotide; Polyazamacrocycle derivatives; Miscellaneous compounds; Pyrimidine; Purine; FMAU 4; deoxyguanosine 2 CDG; DHBV; Pronucleotides; glycosylation Inhibitors; Antisense Oligonucleotides m RNA; Translation; Phenylporpenamide; Screening; Transfected Cell LInes; CCC DNA; DMEM RPMI; Cytootxicity; lamivudine; famciclovir; Baculoviruses infected Hepatoma; Viral Polymerase Assay; Priming Reverse Transcriptase; Duck Model Infection; Carbocyclic; deoxyguanosine CDG; Ganciclovir Penciclovir; Adefovir Dipivoxil; Thymidine; cytidine; Drug Therapy; Lobucavir; Entecavir

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1381612003400740

Publication date: 2000-03-01

More about this publication?

• Current Pharmaceutical Design publishes timely in-depth reviews covering all aspects of current research in rational drug design. Each issue is devoted to a single major therapeutic area. A Guest Editor who is an acknowledged authority in a therapeutic field has solicits for each issue comprehensive and timely reviews from leading researchers in the pharmaceutical industry and academia.
  
  Each thematic issue of Current Pharmaceutical Design covers all subject areas of major importance to modern drug design, including: medicinal chemistry, pharmacology, drug targets and disease mechanism.

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