Molecular Targets in Cancer Drug Discovery: Cell-Based Profiling

Authors: Weinstein, J.N.; Buolamwini, J.K.

Source: Current Pharmaceutical Design, Volume 6, Number 4, 1 March 2000 , pp. 473-483(11)

Publisher: Bentham Science Publishers

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Abstract:

The phrase molecular target-based drug discovery usually implies an in vitro biochemical assay or battery of assays. One portion of the U.S. National Cancer Institutes drug discovery program, to the contrary, examines molecular targets for cancer therapy in a cell-based format. That approach has a number of sig-nificant limitations, but it has produced databases of significant utility on the activities and structures of tested compounds, as well as on molecular characteristics of the cell types used for testing.

Keywords: cel based profiling; molecular target; cacer genome; NCI cell screen; anticancer agents; protein expression

Document Type: Review article

DOI: 10.2174/1381612003400894

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